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Pharmacologic approaches to glycemic treatment: standards of care in Diabetes-2025

The GLP-1 boom is tangible in the food industry

A patient information form

A retrospective study conducted at the University Health Network found that, in liver transplant recipients with diabetes, combination therapy reduced HbA1c and alanine aminotransferase levels more effectively than DPP-4 inhibitors. Additionally, two clinical trials in patients with Type 2 diabetes demonstrated that combination therapy significantly lowered HbA1c by 1.34% and 1.21%, compared to a 0.54% reduction with placebo, starting from a baseline of 8.0%. These findings suggest that combination therapy may be especially beneficial in the liver transplant population, where patients often experience weight gain and develop metabolic co-morbidities

On GLP-1, this compounds the already-slowed digestion and dramatically increases nausea risk

This study was further funded by the French National Research Agency (ANR-10-LABX-46 [European Genomics Institute for Diabetes]) to A.B