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Anyone on long-term metformin should have B12 tested annually

Vitamin B-12 is the source of coenzymes for the respective methylation of homocysteine by 5-methyltetrahydrofolate (5-methylTHF) to form methionine and for the mitochondrial conversion of methylmalonyl-CoA to succinyl-CoA ( Figure 1 )

Forms a balanced, long-term process of weight control and wellness

For information about other supplements that may help, see our answer to the question: Do any supplements, foods, or oils help reduce muscle pain, muscle cramps, or nighttime leg cramps

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