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Adherence to exercise Often, individuals with obesity feel embarrassment surrounding exercising in public spaces due to fear of being viewed poorly compared to those they believe are more fit, attractive, or competent [50]

Quick dramatic changes more likely indicate inflammatory response than genuine improvement

Therefore, it is possible that the selection against KEAP1 sgRNAs in the context of the screen is related to the induction of these and other NRF2 targets

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