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Characterized by insulin resistance, gradual progressive loss of insulin secretion by -cells, and being heavily driven by being overweight or obese [98], T2DM leads to hyperglycemia, excessive urine production, increased risk of cardiovascular disease, and changes in energy metabolism [106]

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Upcoming weight-loss medications As many options as there are right now, there will likely be more in the future thanks to the promising weight-loss medications on the horizon, according to Kushner

Diabetes Care 36 , 34603468 (2013)