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This window accounts for tissue depot retention beyond serum clearance (which occurs within 30 hours based on the peptides 46 hour half-life) and individual metabolic variation

We dont have all the evidence yet but its a pathophysiological clue worth pursuing

Similarly, stimulant laxative use was more frequent among patients with a high maximum daily defecation frequency (5 times/d

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hemodialysis Hemodialysis might be the most effective therapy overall for valproic acid-induced hyperammonemia (since it removes ammonia, valproic acid, and perhaps some of the valproate metabolites)