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Keap1 binds to Cul3 via its BTB domain, forming the Keap1-Cul3-RBX1 E3 ligase complex, which plays a crucial role in the ubiquitination of NRF2 [88, 89]

Therefore, inhibition serine biosynthesis by NCT503, an inhibitor of PHGDH, markedly enhanced the cytotoxicity of carboplatin when both serine and glycine were removed (Fig

Introduction to a More Sophisticated Approach: The Sulfur Protocol A more nuanced approach to optimizing sulfur metabolism involves a comprehensive strategy that goes beyond simple supplementation