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Quick answer: SPF alone isnt enough for your skin, as it only evaluates protection against the sun's harmful UVB rays

The factors that lead to depletion of glutathione includes natural ageing process, or the external stressors that include chronic exposure to chemical toxins, cadmium exposure, alcohol use, smoking, pollution, strenuous aerobic activities, dietary factors, ultraviolet (UV) radiation exposure, tissue injury as from burns, ischemia, septic shock, surgery, drugs (such as acetaminophen and adriamycin)

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Schneider MK, Keller M, Scheidegger R

10.1165/rcmb.2019-0177OC Am J Respir Cell Mol Biol

The metabolic pathways promote the development of an immunosuppressive vascular microenvironment, thereby facilitating resistance to chemotherapy [41]