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Administration of LPS, an endotoxin derived from Gram-negative bacteria that activates innate immunity and increases proinflammatory cytokines such as TNF-, IL-6, and IL-1, elevates circulating GLP-1 within 3 hours in mice and humans (57)

doi: 10.1016/j.cmet.2023.11.009 269 McLeanBAWongCKKaurKDSeeleyRJDruckerDJ

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260,261 Owing to its rate-limiting enzymatic activity in NAD + salvage pathway, the elevated expression of NAMPT in the innate immune cells, including macrophages and dendritic cells, further proposed a link between intracellular NAD + levels and inflammation

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