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Safety, tolerability and pharmacokinetics of PL 14736, a novel agent for treatment of ulcerative colitis, in healthy male volunteers

If you have or have ever had Leber's hereditary optic neuropathy (slow, painless loss of vision, first in one eye and then in the other eye)

W.LeeB.et al

Since immune cell trafficking into the CNS is tightly regulated by the blood brain barrier which selectively only allows entry of immune cell subsets required for immune surveillance (80), it remains unknown if CAR-T would efficiently reach senescent cells in the brain parenchyma

A., Thelen, J

These methods are validated and quality-controlled