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Tirzepatide generally produces greater average weight loss than semaglutide because it targets both GIP and GLP-1 receptors rather than GLP-1 alone

More importantly, as a natural chemical molecule, the targets of TMAO in vivo are not fully elucidated

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Taste changes may result from gastrointestinal side effects such as nausea and reflux, dehydration, ketosis from rapid weight loss, or altered gastric emptying caused by the medication's effect on GLP-1 receptors

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doi: 10.1111/j.1365-2567.2007.02687.x 504 HummelenRChangaluchaJButamanyaNLKoyamaTECookAHabbemaJDFet al