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Research has found that autophagy can exert protective effects through multiple pathways, such as enhancing the regenerative capacity of satellite cells, reducing oxidative stress damage, and inhibiting abnormal inflammatory responses, etc

The reasoning was two-fold: The higher metformin dose may actually help with the constipation, and the two drugs work synergistically they complement each other in ways that can enhance overall effectiveness

Reduction of depression in diabetes: a new pleiotropic action of metformin

Methylmalonic acid (MMA) and homocysteine levels become elevated in B12 deficiency and offer greater sensitivity, particularly for detecting early or functional deficiency, though MMA rises in renal impairment and availability of these tests varies

doi:10.1586/14789450.2014.965159

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