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When mucosal healing is achieved in both Crohns disease and UC, a patient is less likely to have flare-ups, hospitalizations or surgeries

Godin-Ethier, J., et al

298 , E117E126 (2010)

When Nrf2 is activated, it triggers the transcription of genes that detoxify reactive oxygen species (ROS) and eliminate damaged cellular components

Most resolve with dose stabilization and time

J Exp Med 182:178592, PMID: 7500023 Neuschwander-Tetri BA, Bellezzo JM, Britton RS, Bacon BR, Fox ES (1996) Thiol regulation of endotoxin-induced release of tumor necrosis factor a from isolated rat Kupffer cells