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The trans effect determines the polarizability of the CoC bond so formed

PMID 18344392

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pagophagia is so specific to iron deficiency it is considered diagnostic Sore or smooth tongue (atrophic glossitis), cracks at the corners of the mouth (angular cheilitis) Mood changes anxiety, low mood, irritability tied to disrupted dopamine synthesis Heart palpitations or a racing pulse If you are losing more hair than usual, fatigued despite sleeping well, or notice ice cravings, run a ferritin test before assuming the cause is something else