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For long-term, systemic support of skin tone, internal supplementation is generally considered more effective

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Separately, GHK-Cu has been found to stimulate fibroblast proliferation while upregulating genes for collagen, elastin, dermatan sulfate, chondroitin sulfate, and decorin key structural components of the skin's extracellular matrix and to modulate matrix metalloproteinases (MMPs) and their inhibitors, which supports balanced remodeling rather than excessive breakdown or fibrosis

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Malabsorption may be caused by certain autoimmune conditions