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Neurology (2000) 54:S1015

Higher affinity means the ligand and receptor stay bound at lower concentrations

Both MT-2 and leptin are thought to cause an increase in TRH expression in the paraventricular nucleus of the hypothalamus, a region of the brain associated with satiety and food intake, but only MT-2 crosses into the central nervous system in concentrations high enough to have an effect on TRH expression

Elevated cortisol causes a cascade of issues including increased fat storage, muscle breakdown, immune suppression, and sleep disruption

Key to science: Notice new things The most brilliant thing you can do isnt necessarily develop new things

Troy Watsons program stands out for its combination of science and accountability