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This synergistic pathogenic mechanism, involving multiple targets and pathways, provides a crucial theoretical foundation for antioxidant treatments and targeted intervention strategies in PCa ( Figure 2 )

If conservative measures fail after 46 weeks, or if specific pathology is identified, referral to appropriate specialists (physiatry, orthopedics, neurosurgery, pain management, or rheumatology) may be warranted

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Amino Acids 34 (2), 315320