Organ-Specific Warnings: Internal Analgesic, Antipyretic, and Antirheumatic Drug Products for Over-the-Counter Human UseLabeling for Products That Contain Acetaminophen
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Sener S, Akbas A, Kilinc F, Baran P, Erel O, Aktas A
There is only the case of the nuclear transcription factor c-Jun that, due to an unusual redox potential, could react with GSSG at relatively high ratio of GSH/GSSG = 13 ( S -glutathionylation within the cells involves reaction of the critical cysteine on protein or GSH with a corresponding oxidized derivative such as S-nitrosyl ( S -NO), sulfenic acid ( S -OH), thiyl radical ( S )
Unlike most peptides that originate from nuclear DNA, MOTS-c is encoded within the mitochondria, offering unique metabolic effects at the cellular energy level