Side effects reported during the trials included nausea, vomiting, diarrhea, and constipation, but patients characterized these effects as mild and temporary
However, based on the pharmacological similarity to other incretin-based therapies, similar weight regain is expected once treatment ends
Although periconceptional exposure to GLP-1 receptor agonists has not shown an increased risk of malformations, data on complications such as fetal growth restriction or embryonic death are lacking [188]
Acute kidney injury Acute kidney injury is a rare but serious side effect reported with Mounjaro, most often linked to severe dehydration from ongoing vomiting or diarrhoea
What these drugs seem to be doing is creating a cultural moment where consumers are thinking more about losing weight
MC4R agonist targets central POMC/MC4R pathway in hypothalamus