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Gut hormones not only finely regulate the secretion of pancreatic hormones through the brain-gut axis, but also influence central appetite and energy balance regulation via the same pathway, thereby indirectly affecting systemic insulin sensitivity

Evidence also indicates GLP-1 therapy produces cardiovascular and metabolic improvements beyond weight loss alone, including reductions in blood pressure, inflammatory markers, and fatty liver disease risk

vulnerability is systematically underestimated and often poorly understood

Balercia G, Regoli F, Armeni T, Koverech A, Mantero F, Boscaro M

This can be detrimental to the benefits of semaglutide, particularly if youre taking the drug for kidney disease

Nejati, R., Bijeh, N., Rad, M.M