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Free Radic Biol Med 25(6):682687 Pereira MD, Herdeiro RS, Fernandes PN, Eleutherio ECA, Panek AD (2003) Targets of oxidative stress in yeast sod mutants

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Weight loss compared to placebo was ~5% in RCTs

At relatively lower concentrations, passive transport dominates, while higher concentrations trigger active transport mechanisms, leading to reduced absorption rates into the ileum (99)

Or if they go back to the old ways after stopping the medication, they may regain weight