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16 More recently, the FLOW trial enrolled 3,533 patients with T2D and CKD (estimated glomerular filtration rate [eGFR] 5075 ml/min/1.73 m 2 with an albumin-to-creatinine ratio of 3005,000 or eGFR 2549 ml/min/1.73 m 2 with an albumin-to-creatinine ratio of 1005,000)

Zhen, X

Because both semaglutide and tirzepatide share GLP-1 receptor activation as a core mechanism, a patient with suboptimal GLP1R receptor function may have a biological ceiling that neither drug can push past regardless of dose

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J Neurosci 28:50075017