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In addition, it has been found that most natural polyphenols play an antioxidant role by activating the Nrf2 and GPX4-related pathways, thereby playing an important role in the treatment of diabetes and its complications (228, 229, 236)

Other contraindications include allergies to the compounds, severe renal and hepatic diseases, and a history of skin cancer

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Existing findings indicate that the protective mechanism is mainly attributed to the GLP-1 signaling pathway, which involves cyclic adenosine monophosphate (cAMP), protein kinase A (PKA) and cAMP response element-binding protein (CREB)