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doi: 10.1097/MCC.0000000000001294 40

Our studies have some limitations, including the use of two distinct promoters to drive cre expression for targeting Gipr versus Glp1r in the brain, and the non-CNS exclusive pattern of Wnt1 expression, which also targets the enteric nervous system

Studies and adverse event reports have raised concerns about a potential association between GLP-1 agonists and NAION, a serious eye condition involving reduced blood flow to the optic nerve

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