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Those with very dry skin should begin with PM-only use and build to twice daily.
10.1016/s0140-6736(18)31948-2 113 MaoC.LiuX.ZhangY.LeiG.YanY.LeeH.et al (2021)
The mechanisms of CDDP-associated hearing loss have been described to include oxidative stress, DNA damage, inflammation, and induction of cell death pathways such as apoptosis, necroptosis, and ferroptosis
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