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When the somatostatin decreases, the signaling pathway for the regulation of growth hormone levels drops

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Setmelanotide is being tested in Bardet-Biedl syndrome and Alstrm syndrome in a phase 3 trial (NCT03746522), as well as SRC1, SH2B1, and MC4R deficiency, and Smith-Magenis syndrome in a basket Phase 2 trial (NCT03013543)

Kiasalari, T

The long-term safety of these medications, including their potential associations with cancer risk and other uncommon events, warrants further investigation, the authors added

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