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European Association for the Study of Diabetes (EASD) 60th Annual Meeting

And that's kind of what we say

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At the end of the study, the authors observed improved dermal density, reduced periorbital wrinkles, and skin smoothness in the treatment group

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Common Clinical Use The most commonly used PDE-4 inhibitor is roflumilast, indicated for: Severe COPD associated with chronic bronchitis Patients with frequent COPD exacerbations It is usually used as add-on therapy to bronchodilators