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Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy

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The aforementioned observations prompt the question of whether NF-B directly regulates EAAT3 expression at the transcriptional level

Taken together, these biochemical results suggest that ultraviolet irradiation of the skin causes changes compatible with aging that manifest as a reduction in the content of pro-collagen type 1, elastin and sulfated GAGs, as well as an increase in MMP1 activity, and the CG treatment reverses these changes by increasing the levels of these extracellular matrix components, except for MMP1 activity, which can be attributed to its rejuvenating effect

Huesca-Uristegui K, Garca-Valderrama EJ, Gutierrez-Uribe JA, Antunes-Ricardo M, Guajardo-Flores D