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22, 23 In children with GHD, changes were identified in MAPK- and GRB2/SOS-mediated signaling pathways (e.g., IGF-I) associated with carriage of the A allele ( GRB2 decreased expression 1.2-fold, SOS1 increased expression +1.2-fold)
It has also been reported that prostaglandin E2 (PGE2) secretion and cyclooxygenase-2 (COX-2) expression were significantly increased in colon cells exposed to toxin A either in vivo or in vitro (Kim et al., 2007)
