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and that the rate is substantially diminished by groups, for example, ortho substituents in benzamides, which shield the reaction centre from attack by other molecules 3 4

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The expression of GST A3-3 in steroidogenic tissues suggests that the enzyme has evolved to support the activity of 3-hydroxysteroid dehydrogenase, which catalyzes the formation of 5-androsten-3,17-dione and 5-pregnen-3,20-dione that are substrates for the double-bond isomerization catalyzed by GST A3-3

Because of its low baseline absorption, oral doses of SAMe must be relatively high to achieve therapeutic effects, particularly for severe symptoms