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Especially for individuals with high peripheral iron levels, DFP might be less efficacious due to the potential iron chelation in peripheral tissues

Favorable reimbursement coverage across developed markets and strong commercial penetration have supported widespread adoption

Its proposed mechanisms include the promotion of angiogenesis (formation of new blood vessels), enhancement of collagen production, and support of the gut-tissue axis for improved gut health

This suggests that in IBD, barrier breakdown may be caused by Paneth cell loss

The first month is often an adjustment period, but "adjusting" should not become a reason to dismiss significant symptoms

Barrett AW, Raja AM