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Key Points Tumor necrosis factor (TNF) was the first cytokine to be fully validated as a therapeutic target for rheumatoid arthritis (RA) Combination therapy with an anti-TNF biologic agent plus methotrexate halts progression of joint damage in the majority of patients with RA, irrespective of the extent of destruction on baseline radiography Studies of patients with early RA receiving anti-TNF therapy show particularly favorable outcomes

Additional preclinical work would be quite valuable to address this, added Rinaman

It's a preliminary screening step, not a clinical decision

Dietary gluten-induced gut dysbiosis is accompanied by selective upregulation of microRNAs with intestinal tight junction and bacteria-binding motifs in rhesus macaque model of celiac disease

The global gap in treatment coverage for major depressive disorder in 84 countries from 20002019: A systematic review and Bayesian meta-regression analysis