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however, current evidence remains limited, heterogeneous, and derived largely from secondary analyses or observational studies rather than dedicated randomized heart failure trials
Importantly, it also led to a reduction in HIF-1 expression, indicating that restoring local oxygen availability can directly influence gene regulation (Figure 2 for details)
Stepanas AV, Samaan NA, Hill CS Jr, Hickey RC
It upregulates the expression of anti-inflammatory genes, including NF-BIA , MAP3K8 , and TLR5 , while concurrently downregulating pro-inflammatory genes such as TNFSF6 , TNF- , and nuclear factor-B ( NF-B ) [36,37,38,39]
Chakraborty, Nandi S, Mishra P, Niharika J, Roy A, Manna S, et al