Begin gradually shifting from strict tracking to mindful eating, while keeping weekly weigh-ins as a safety net
Close monitoring of blood sugar is essential, particularly if you frequently feel tired, to allow for timely adjustments to medication or diet
Recovery may require additional attention due to the caloric deficit, making adequate sleep and protein intake particularly important
Stretch marks often begin as red or purple marks, and slowly fade to white or silver over time
Research published in Diabetes has shown that GLP-1 receptor activation in the central nervous system directly reduces food intake (Turton et al., 1996) Slowed gastric emptying GLP-1 delays how quickly food moves from the stomach into the small intestine, prolonging satiety after meals Enhanced insulin secretion GLP-1 stimulates glucose-dependent insulin release from pancreatic beta cells, helping regulate blood sugar without causing hypoglycemia Glucagon suppression Paradoxically, while retatrutide also activates the glucagon receptor directly, GLP-1 pathway activation suppresses inappropriate glucagon release after meals, helping stabilize postprandial blood sugar This is the same pathway that semaglutide targets, and it accounts for much of the appetite suppression that weight loss medications produce
In this issue of the JCI, Knauf et al
