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An open-label trial by Mansur et al 23 reported that addition of liraglutide 1.8 mg daily to the existing medication regimen led to significant increases from baseline to week 4 in the Trail-Making Test-B standard score and in a composite Z-score comprising multiple cognitive tests

Studies using mouse and cellular models indicate that prolonged hypernutrition increases hepatic concentrations of TNF- and IL-1, which promote TREM2 shedding via ADAM17-dependent proteolytic cleavage