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The ferroptosis pathway involves several critical mechanisms: iron uptake via transferrin receptor, ferritinophagy mediated by nuclear receptor coactivator 4 (NCOA4), iron export through ferroportin regulated by hepcidin, accumulation of lipid peroxides via the Fenton reaction, and antioxidant defense via glutathione peroxidase 4 (GPx4) and glutathione (GSH)

Front Cell Dev Biol 13(10):857022 Toda S, Segawa K, Nagata S (2014) MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands

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