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Furthermore, an upregulation of miR-212 and miR-29c, both involved in the regulation of the expression of the mentioned genes, was also observed in both normal and high glucose conditions

Studies have examined the dose-response relationships for MC1R-mediated melanogenesis with MT-II , comparing potency with MT-1 and native -MSH to establish the structure-activity contribution of cyclisation to MC1R agonist potency , and have characterised the kinetics of tyrosinase upregulation, melanosome distribution, and melanin transfer to keratinocytes downstream of MT-II-induced MC1R activation

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Pull back on the plunger slowly to avoid introducing air bubbles