Important considerations include: GLP-1 agonists are generally well-tolerated in people with hypertension They do not typically cause dangerous drops in blood pressure Dehydration from gastrointestinal side effects (nausea, vomiting, diarrhoea) can occasionally affect blood pressure and kidney function, so maintaining adequate fluid intake is important If you take diuretics (water tablets), ACE inhibitors or ARBs for blood pressure, your doctor may monitor you more closely during the initial weeks of GLP-1 therapy Seek medical advice promptly if you experience persistent gastrointestinal symptoms that prevent adequate fluid intake NICE guidance (NG28) supports the use of GLP-1 agonists in people with type 2 diabetes who meet specific criteria, with preference for agents with proven cardiovascular benefits in those with established cardiovascular disease
Dinh Tran, MD at Family Healthcare Shoreline for Oral GLP-1 Weight Loss
Chemogenetic activation of GLP-1R neurons in the ARC, particularly neurons co-expressing POMC and GLP-1R in male mice, significantly suppressed feeding [86,87]
Digestive Side Effects Nausea, diarrhea, and vomiting are the most commonly reported occasional side effects
PlexusDx offers both oral and injectable tirzepatide, plus GLP-Squared combination formulations, allowing providers to select the strongest option for each patient's response profile
We are used to doing informed consent for surgery and procedures but not equally good at doing informed consent before prescribing medications
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