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GLP-1 Receptor Activation: A Well-Mapped Pathway With Tirzepatide Nuances Tirzepatide's GLP-1R agonism shares a pharmacological family with semaglutide and liraglutide but carries structural differences that affect receptor residence time and downstream bias

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10.1542/pir.27-12-443 Pediatr Rev

10.1186/s13024-019-0314-8 69 TysnesO

Although more PD models are needed to validate whether PKM2 is a universal therapeutic target in PD, our results provide preliminary evidence that dimerizing PKM2 is a potential therapeutic approach to protect nigral dopaminergic neurons from oxidative damage