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Clinical Management If glucocorticoid therapy cannot be paused, consider timing sermorelin injections at least 4 hours after the last glucocorticoid dose to take advantage of the circadian nadir of endogenous cortisol

Abbreviations, HMs, heavy metals

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83 Oxidation of BH 4 not only reduces BH 4 bioavailability but also the oxidation products such as BH 2 may compete with BH 4 for binding to eNOS, 90 thereby leading to eNOS uncoupling