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Cyanocobalamin (vitamin B12) functions as a cofactor in methylmalonyl-CoA mutase and methionine synthase pathways involved in fatty acid metabolism and cellular energy production

The SURPASS phase 3 clinical trial programme explored the efficacy and safety of tirzepatide in people with type 2 diabetes, and demonstrated dose-dependent reductions in HbA 1c of 2028 mmol/mol in those treated with tirzepatide: greater reductions than those achieved with semaglutide (Fras et al, 2021), insulin degludec (Ludvik et al, 2021) and insulin glargine (Del Prato et al, 2021), with reductions sustained up to 2 years in SURPASS-4

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So, eating more high-fiber, high-volume foods can boost gut health (6)

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