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Weekly injections may be all it takes for some people to feel better, while others may need more frequent dosing to feel their best

[5] Systemically elevated estradiol exerts negative feedback on the hypothalamic-pituitary-gonadal axis, reducing secretion of luteinizing hormone and follicle-stimulating hormone, a property leveraged therapeutically in certain hypoestrogenic states to stabilize hormonal milieu and mitigate vasomotor volatility

Rarely, some people experience mild nausea or dizziness

But my rehab is very similar regardless of the pathology

The difference between topical and injectable is not a marginal efficiency gain

However, younger adults are not safe, and B12 deficiency can result from stress, poor nutrition and certain medications like antacids or diabetes drugs