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Complications of ulcerative colitis Possible complications associated with ulcerative colitis that may be life-threatening are: Perforated colon, also known as a hole in the colon Toxic megacolon, also known as the rapid swelling of the colon Excessive bleeding Inflammation in the eyes, joints, and skin Increased risk of developing blood clots in arteries and veins Increased risk of developing colon cancer Available treatments for ulcerative colitis In order to assess the best treatment, your doctor or gastroenterologist may run a series of tests that includes blood tests, stool tests, colonoscopy, and CT scans