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The experimental protocol was approved by the local Institutional Animal Care and Use Committees (ORBEA UC 04-2015

The updated 2022 CAD-RADS 2.0 classification will follow a framework of stenosis, plaque burden and modifiers, with the option to also include ischemia evaluation by CT fractional-flow-reserve (CT-FFR) or myocardial CT perfusion (CTP), if performed

Notably, Nrf2/HO-1 inhibits the overexpression of the key inflammatory mediator cyclooxygenase-2 (COX-2), resulting in an anti-inflammatory effect

Other Considerations: Monitoring: Regular monitoring of vitamin B12 levels, complete blood counts, and neurological function is advisable, especially in long-term use

Proteins are also made from amino acids, but peptides are smaller