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c-Myc can directly bind to the promoter regions of PHGDH and PSAT1 and promote their transcription, a mechanism that has been validated in breast cancer and glioblastoma ( In non-small cell lung cancer, NRF2 upregulates the expression of PHGDH, PSAT1 and SHMT2 by activating ATF4, thereby driving SSP activation, which is associated with poor clinical prognosis ( de novo serine synthesis by binding to the PHGDH promoter and repressing its transcriptional activity, thereby inhibiting tumorigenesis ( 5.2 Epigenetic regulation mRNA modifications are also implicated in the regulation of the de novo serine synthesis pathway

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