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If this happens, throw the needle in a sharps container and start over

Despite their utility, a significant challenge in iHLO research lies in determining the optimal developmental timepoints for liver-like functionality, which is critical for their effective use in pharmacological and toxicological studies

In diet-induced obesity (DIO) models, NNMT loss-of-function and selective small-molecule inhibitors reduce white adipose mass and improve metabolic parameters without overt toxicity, positioning NNMT as a tractable target for metabolic-disease research [24]

Jan 23 2021;397(10271):319-333

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