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thanks the Plant Genomics and Breeding Center (CGF) and the Federal University of Pelotas (UFPel) for their support during my doctoral studies

Future Directions While preclinical data are compelling, human trials are needed to validate efficacy and dosing

Immunity 40 , 128139 (2014)

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In conclusion, the hypoxiaHIF1VEGF pathway regulates inefficient vasculature, which sustains tumor cell metabolism, facilitates dissemination, and reinforces immunosuppression (117, 118)