Glutathione depletion by buthionine sulfoximine induces oxidative damage to DNA in organs of rabbits in vivo
[DOI] [PMC free article] [PubMed] [Google Scholar] 8.Cuenod M., Steullet P., Cabungcal J.H., Dwir D., Khadimallah I., Klauser P., Conus P., Do K.Q
An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection
However, we are exposed to toxins daily and our bodies need help to remove these toxins
Figure 3: Acetaldehyde, a byproduct of alcohol, disrupts the balance of SAM and SAH, increasing homocysteine (Hcy) conversion to methionine while reducing cysteine and glutathione (GSH) production
CHAC1 emerges as a key stress-responsive effector, transcriptionally upregulated via the ATF4-CHOP axis during endoplasmic reticulum stress and amino acid deprivation