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Furthermore, Fer-1 mitigates oxidative stress by downregulating prostaglandin endoperoxide synthase 2 while upregulating GPX4 and Nrf2, thereby decreasing lipid peroxidation (115)

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Specifically, the infralimbic (IL) and prelimbic (PL) regions of the PFC modulate fear extinction, with IL activation shown to facilitate this process in animal models

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