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Beyond simple biomechanics, where each 1 kg of weight gain multiplies knee joint load by 34 kg, accelerating cartilage wear and activating pathogenic pathways like Wnt/ -catenin, the endocrine function of fat is paramount (14, 15)

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The absence of strong appetite stimulation differentiates its systemic profile

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The World Anti-Doping Agency bans most peptides in competitive athletes, and clinical oversight is advised when using hormone-targeting peptides

Cocaine also exhibits nonselective inhibition of dopamine (DAT) and serotonin (SERT) transporters, elevating multiple neurotransmitters, particularly in the CNS