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Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling

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Its observed effects may include modulation of feeding behavior, reduction in energy intake, and stabilization of glucose homeostasis in experimental subjects

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For assessing the safety and pharmacokinetics of oral semaglutide in healthy subjects and subjects with type 2 diabetes, the drug was measured in plasma after protein precipitation using LC-MS/MS with a lower Limit of quantification of 0.73 nmol/L [80]

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